Track 13: Paget’s Disease of the Breast:-

Paget’s Disease of the Breast Meaning & Definition:-
An uncommon disorder connected to breast cancer is Paget’s disease of the nipple, also known as Paget’s disease of the breast.
The skin around the nipple and the region of darker skin develops eczema-like changes as a result (areola). In the tissue beneath the nipple, breast cancer is often evident.
Paget’s disease of the nipple affects 1 to 4 percent of breast cancer patients in females. Men may also be impacted, although this is quite uncommon.
To differentiate the ailment from Paget’s disease of the bone, it is referred to as Paget’s disease of the nipple (where bones become weak and deformed).
Paget’s disease of the nipple signs:-

  • The areola may also be affected by Paget’s disease of the nipple, which always begins in the nipple. Nipple and areola skin develops a red, scaly rash as a result.
  • Itchy or burning sensations may also be experienced, and the afflicted skin is often painful and swollen. Sometimes there might be an ulcer on the nipple.
  • The rash often resembles other skin illnesses, such eczema or psoriasis, in terms of appearance. Scratching it or ignoring it might cause it to bleed, develop into an ulcer, or scab over.
  • Paget’s disease of the nipple is unlikely to be the cause of itching, burning, or bleeding if the nipple seems normal and is not red or scaly. You should still see a doctor to get it examined, however.
  • A lump behind the nipple is seen in around 50% of women with Paget’s disease of the nipple. This breast cancer is invasive in 90% of instances.
  • When malignant cells infiltrate the tissue around the breast, it is called invasive cancer. Even if they don’t have a lump, some Paget’s disease patients have invasive breast cancer.
  • The majority of Paget’s disease sufferers who do not have a lump, meanwhile, have non-invasive cancer.
  • Here, the malignant cells have not disseminated outside of one or more specific breast regions.
    Paget’s disease of the nipple causes:-
  • Paget’s disease of the nipple has an enigmatic origin. Although Paget’s illness is not explicitly a concern for certain women, breast cancer does seem to be. An identifiable cause of a particular form of breast cancer is unknown.
  • According to risk factors, you have a higher chance of getting breast cancer if you:
  • Are older, since ageing raises the chance of acquiring breast cancer
  • Have close family members that have breast cancer
  • Already had breast cancer
  • Having previously had a benign (non-cancerous) breast condition – Only a very tiny percentage of women experience this link between specific benign breast disease types and an elevated risk of breast cancer.
  • Are overweight, especially if you have had menopause (you may determine if you are overweight or obese using the BMI healthy weight calculator).
  • Drink a lot of alcohol since the more you consume, the higher your risk is.
    Paget’s disease of the nipple diagnosis:-
  • If you observe any changes in the skin of your areola or nipple, you should see your doctor.
  • The sooner Paget’s disease of the nipple is discovered, the better the prognosis is likely to be since it is connected to breast cancer.
  • If a breast lump appears, you should also see your doctor. It’s crucial to get breast lumps examined even if the majority of them are not malignant.
  • When Paget’s disease of the nipple is suspected, a biopsy is done to confirm the diagnosis. Your nipple will be punched to get a little tissue sample, which will then be inspected under a microscope to see if it contains any malignant cells.
  • You will have a mammogram (a low-dose breast X-ray) to further explore whether the biopsy findings show Paget’s disease.

Treating Paget’s nipple illness:-

  • The primary form of therapy for Paget’s disease of the nipple is surgery. Surgery will either include removing the whole breast (a mastectomy) or the nipple and areola along with the breast tissue underlying them, depending on whether the cancer has progressed (a central excision).
  • Breast reconstruction surgery may be done to produce a breast shape that matches the surviving breast if your whole breast is removed.
  • If you have invasive breast cancer, you could also need further therapy. This might include a mixture of:
  • Chemotherapy: the employment of powerful drugs to kill malignant cells
  • Using precise dosages of high-energy radiation, radiotherapy eliminates malignant cells.
  • Targeted or hormone treatment reduces the likelihood that cancer may recur in the same breast (and impact the other breast), as well as the likelihood that malignant cells will move to other parts of the body.

A complete recovery is likely if Paget’s disease is identified and treated in its early stages.

Track 13: Paget’s Disease of the Breast:-

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Subtopics of Paget’s Disease of the Breast:-

  1. What does Paget’s disease of the breast feel like?
  2. Is Paget’s disease always cancer?
  3. How long can you live with Paget’s disease of the breast?
  4. Can Paget’s disease of the breast be cured?
  5. Paget’s disease of the breast symptoms
  6. Paget’s disease of the breast treatment
  7. Is paget’s disease of the breast fatal
  8. Early stage paget’s disease breast pictures
  9. Paget’s disease breast stories
  10. Worried about Paget’s disease

Breast Cancer Association:- 

  1. European Neurofibromatosis Association
  2. European Oncology Nursing Society
  3. European Organisation for Research and Treatment of Cancer
  4. European Organisation for Research and Treatment of Cancer-Gynaecological Cancer Group
  5. European Organisation for Treatment of Trophoblastic Disease
  6. European Prostate Cancer Coalition European Research Organization on Genital Infection and Neoplasia
  7. European School of Oncology
  8. European Society for Medical Oncology
  9. European Society for Therapeutic Radiation and Oncology
  10. European Society of Breast Cancer Specialists

Breast Cancer Society Universities:-

  1. National Cancer Institute (NCI)
  2. National Breast Cancer Foundation
  3. JNCI: Journal of the National Cancer Institute
  4. Nottingham Breast Cancer Research Centre
  5. The University of Manchester
  6. Rumbaugh-goodwin institute for cancer research
  7. Brad wisdom american cancer society
  8. University of Utah
  9. ACS – American College of Surgeons
  10. University of Otago

Breast Cancer Association Society:-

  1. Sebeccly Cancer Care & Support Centre
  2. Cancer Connect GH
  3. Esophageal Cancer Awareness Association (ECAA)
  4. Venezuela Breast Cancer and Education Foundation
  5. LALCEC (Argentinian League of the Fight Against Cancer)
  6. UT Southwestern’s Harold C. Simmons Cancer Center
  7. National Cancer Institute
  8. American Cancer Society
  9. Canadian Cancer Society
  10. Melanoma Network of Canada

Breast Cancer Companies:-

  1. Qritive
  2. Onconova Therapeutics
  3. Juno Therapeutics
  4. Refuge Biotechnologies
  5. Biotheranostics
  6. ProMIS Neurosciences
  7. Avidity Biosciences
  8. Cellectis
  9. SF17 Therapeutics
  10. Argonaut Therapeutics